Error 500 may be caused by network issues at your end. But since the websites are opening in MS Edge we can rule that out.

Can you please try the Safe mode/troubleshooting mode of Firefox to see if you are still facing the issue? Go to menu > Help > Troubleshoot Mode

Refer to the KB article Diagnose Firefox issues using Troubleshoot Mode for more details.

If the issue still persists in Troubleshooting mode then please check if the issue still occurs when you use a new profile

1. Create a New Profile New Profile.
2. Close all the open instances of Firefox browser
3. Relaunch Firefox by running the following command firefox.exe -P.
4. Select the profile created in the first step
5. Once the profile loads please make sure that you do not add any new extension or change any Firefox setting in the new profile before proceeding.
6. Now check if the websites load properly.

Can you share a link to the page?

You can try these steps in case of issues with webpages:

You can reload webpage(s) and bypass the cache to refresh possibly outdated or corrupted files.

• hold down the Shift key and left-click the Reload button
• press "Ctrl + F5" or press "Ctrl + Shift + R" (Windows,Linux)
• press "Command + Shift + R" (Mac)

Clear the Cache and remove the Cookies for websites that cause problems via the "3-bar" Firefox menu button (Settings), click the padlock icon (Clear cookies and site data) for the domain in the selected tab.

"Remove the Cookies" for websites that cause problems:

• Settings -> Privacy & Security
  Cookies and Site Data: "Manage Data"

"Clear the Cache":

• Settings -> Privacy & Security
  Cookies and Site Data -> Clear Data -> [X] Cached Web Content -> Clear

• https://support.mozilla.org/en-US/kb/clear-cookies-and-site-data-firefox
• https://support.mozilla.org/en-US/kb/how-clear-firefox-cache

Start Firefox in Troubleshoot Mode to check if one of the extensions ("3-bar" menu button or Tools -> Add-ons -> Extensions) or if hardware acceleration or if userChrome.css/userContent.css is causing the problem.

• switch to the Default System theme: "3-bar" menu button or Tools -> Add-ons -> Themes
• do NOT click the "Refresh Firefox" button on the Troubleshoot Mode start window

• https://support.mozilla.org/en-US/kb/diagnose-firefox-issues-using-troubleshoot-mode
• https://support.mozilla.org/en-US/kb/troubleshoot-extensions-themes-to-fix-problems

You can check for issues with Enhanced Tracking Protection. Firefox shows a purple shield instead of a gray shield at the left end of the location/address bar in case Enhanced Tracking Protection is blocking content.

• click the shield icon for more detail and possibly disable the protection

You can check the Web Console for relevant-looking messages like blocked content.

• https://support.mozilla.org/en-US/kb/enhanced-tracking-protection-firefox-desktop
• https://support.mozilla.org/en-US/kb/total-cookie-protection-and-website-breakage-faq
• https://support.mozilla.org/en-US/kb/trackers-and-scripts-firefox-blocks-enhanced-track