Hopefully it's just a quick settings change but a bad add-on or other malware might be lingering and interfere. Let's start with the setting:

(1) In a new tab, type or paste about:config in the address bar and press Enter/Return. Click the button promising to be careful.

(2) In the search box above the list, type or paste newtab and pause while the list is filtered

(3) Double-click the browser.newtab.url preference and enter your preferred page:

• Page thumbnails (default) => about:newtab
  you can right-click > Reset for this one
• Blank tab => about:blank
• Built-in Firefox home page => about:home
• Any other page => full URL to the page

Press Ctrl+t to open a new tab and verify that it worked. Fixed?

If problems persist, some potential diagnoses and remedies:

If Firefox won't let you edit this setting: you may have something called SearchProtect on your system. This needs to be removed from the Windows Control Panel. If the status says "locked" we will need to help you investigate an "autoconfig" file.

If Firefox lets you save your change but ignores it: one of your extensions may be overriding it. Please see the next reply.

If the change works during your session, but at the next startup is back to the unwanted page: you might have a user.js file in your personal Firefox settings folder (your Firefox profile folder). This article describes how to track down and remove the file: How to fix preferences that won't save.

Any luck?

Here's my suggested procedure for tracking down and cleaning up bad add-ons and other hijackers. I know it seems long, but it's not that bad.

(1) Open the Windows Control Panel, Uninstall a Program. After the list loads, click the "Installed on" column heading to group the infections, I mean, additions, by date. This can help in smoking out undisclosed bundle items that snuck in with some software you agreed to install. Be suspicious of everything you do not recognize/remember, as malware often uses important or innocent sounding names to discourage you from removing it. Take out as much trash as possible here.

(2) Open Firefox's Add-ons page using either:

• Ctrl+Shift+a
• "3-bar" menu button (or Tools menu) > Add-ons
• in the Windows "Run" dialog, type or paste
  firefox.exe "about:addons"

In the left column, click Plugins. Set nonessential and unrecognized plugins to "Never Activate".

In the left column, click Extensions. Then, if in doubt, disable (or Remove, if possible) unrecognized and unwanted extensions. Bear in mind that all extensions are optional, none come with Firefox, and you can learn more about them by checking their reviews on the Add-ons site.

Often a link will appear above at least one disabled extension to restart Firefox. You can complete your work on the tab and click one of the links as the last step.

Any improvement?

(3) You can search for remaining issues with the scanning/cleaning tools listed in our support article: Troubleshoot Firefox issues caused by malware. These on-demand scanners are free and take considerable time to run. If they finish quickly and especially if they require payment, you may have a serious infection. I suggest the specialized forums listed in the article in that case.

Success?