Are there any prefs on the about:config page that have Locked in the status column?

You can click the Status heading to sort by this column.

http://kb.mozillazine.org/Preferences_not_saved

You can check the target line in the Firefox desktop shortcut (right-click: Properties) to make sure that nothing is appended after the path to the Firefox program.

Hello,

Try Firefox Safe Mode to see if the problem goes away. Firefox Safe Mode is a troubleshooting mode that turns off some settings and disables most add-ons (extensions and themes).

(If you're using an added theme, switch to the Default theme.)

If Firefox is open, you can restart in Firefox Safe Mode from the Help menu by clicking on the Restart with Add-ons Disabled... menu item:


If Firefox is not running, you can start Firefox in Safe Mode as follows:

• On Windows: Hold the Shift key when you open the Firefox desktop or Start menu shortcut.
• On Mac: Hold the option key while starting Firefox.
• On Linux: Quit Firefox, go to your Terminal and run firefox -safe-mode
  (you may need to specify the Firefox installation path e.g. /usr/lib/firefox)

Once you get the pop-up, just select "'Start in Safe Mode"

If the issue is not present in Firefox Safe Mode, your problem is probably caused by an extension, and you need to figure out which one. Please follow the Troubleshoot extensions, themes and hardware acceleration issues to solve common Firefox problems article to find the cause.

To exit Firefox Safe Mode, just close Firefox and wait a few seconds before opening Firefox for normal use again.

When you figure out what's causing your issues, please let us know. It might help others with the same problem.

Thank you.

Just in principle, I think the problem is fixed. I will test the solution for some days.