Looking at the last part of the command line - Are you using -P or -p ? In standard desktop Thunderbird it is a -P (dash capital P - not lowercase p)

i should also add that there needs to be a space before the dash.

If using MAC or Linux OS then you would use -profilemanager (all lower case - space dash profilemanger)

Hi. (I am on windows). The result is the same with -p and -P, the both launch the thunderbird and not the Profil Manager.

Ok I've neen searching around on portableapps.com for Thunderbird.

You see you are not actually using Mozilla Thunderbird for desktop, you are using a product that has been modified by a third party and so should really be asking in that products forum.

http://portableapps.com/node/23603 The profile manager isn't portable. Its just not supported by Thunderbird Portable because it will break things.

http://portableapps.com/node/11191

http://portableapps.com/support/thunderbird_portable#local_profile

Thank you for your help and the links. I will have to do everything manualy.