https://support.mozilla.org/en-US/kb/how-to-fix-preferences-wont-save

Note: Some software, like Advanced SystemCare with Surfing Protection, can protect files in the Firefox profile folder against changes. If you have such software then check the settings or uninstall this software.

You may have corrupt sessionstore file(s).

Type about:support in the address bar and press enter.

Under the page logo on the left side you will see Application Basics. Under this find Profile Folder. To it’s right press the button Show Folder. This will open your file browser to the current Firefox profile. Now Close Firefox.

Locate the sessionstore file(s). Then rename or delete them. Restart Firefox.

Note that your System Delete list shows that you have a user.js file in the profile folder to initialize prefs each time Firefox starts. The user.js file will only be present if you or other software has created this file and normally won't be present.

You can check its content with a plain text editor (right-click: "Open with"; do not double-click). The user.js file is read each time Firefox is started and initializes preferences to the value specified in this file, so preferences set via user.js can only be changed temporarily for the current session.

You can delete the user.js file if you didn't create this file yourself.

You can use this button to go to the current Firefox profile folder:

• Help > Troubleshooting Information > Profile Directory: Show Folder (Linux: Open Directory; Mac: Show in Finder)
• http://kb.mozillazine.org/Profile_folder_-_Firefox

Windows hides some file extensions by default. Among them .html and .ini and .js and .txt and you may only see a file name without file extension. You can check the file extension (type) in the properties of the file in Windows Explorer via the right-click context menu.

I found a fix. I refreshed Firefox and reinstalled the add-ons it removed during the refresh. Restarted the PC and it now keeps the option changes I make.

That was very good work. Well Done.