Does TB connect if you run Windows in safe mode? What's the antivirus? What are the IMAP and SMTP server settings?

IMAP outlook.office365.com port 993 SSL/TLS OAuth2 User name same as account name same as email address Thunderbird is 102.14.0 64bit Antivirus is problematic. The PC came with Akamai software installed which I found evil, stopping me from getting any work done. When I tried to delete it, it resisted strenuously and it took me ages to be able to click on the appropriate Microsoft options - Akamai have the ability to blanket the screen denying access to everything with a blanket which cannot be minimised, cancelled or anything else - but I went on and on and eventually it disappeared from my list of applications and everywhere else on my PC whereupon Microsoft took it upon itself to instal its software. However, every now and again I get a popup saying that I need protection against websites from the Akamai software so it is possible that Akamai have left a virus behind that seeks to deny me access to websites I need to access. I think this is unlikely. As I said before, I do have web access to Microsoft email up in parallel so I have access to at least some part of the Microsoft email infrastructure at the point of failure. I do not know what the error message is referring to - what is trying to access what and failing?