I'm '''Win 10''' / Adjust Path for Win X as needed .... Make Shtcuts with following Paths ..... Open TEST Profile – w/ FF default Profile '''Closed''' "C:\Program Files\Mozilla Firefox\firefox.exe" -P TEST (or whatever Profile name) Open TEST Profile – w/ FF default Profile '''Open''' "C:\Program Files\Mozilla Firefox\firefox.exe" -P TEST '''-no-remote''' In any Shtcut script don't forget a '''Split Profile Name requires''' Quotes .... Test, Test2 Don't --- BUT "Test 2" Does. "C:\Program Files\Mozilla Firefox\firefox.exe" -P "TEST 2" I'm not sure IF Profile Mgr varies with Default Profile Closed or Open, BUT a '''Profile Mgr shtcut''' is (default Profile presumed Closed) .... "C:\Program Files\Mozilla Firefox\firefox.exe" -P Make it .... "C:\Program Files\Mozilla Firefox\firefox.exe" -P -no-remote ..... IF Open requires it.