I'm not entirely sure what you mean.

We would need to set a new setting for Firefox via GPO. It is the setting that sets this RegKey:

"Software\Policies\Mozilla\Firefox\SecurityDevices\Add\NAME_OF_DEVICE_TO_ADD = PATH_TO_LIBRARY_FOR_DEVICE".

Depending on what is installed on the client different values would need to be set for the setting.

Is something like this possible via GPO?

Not in Firefox. You would have to do something with Windows to make that happen.

You can put incorrect values in the setting and they will just be ignored, so you could add all the possibilities.