just more info regarding the above -- disabled add ons - no luck. Disabled plug ins - no luck. Disabled autoscrolling - no luck. This makes the browser almost impossible to use. You cannot place the mouse cursor within a field (unless you click TAB first to break the cycle). You cannot click on sequential items on a page. Clicking on desktop then back to firefox sometimes reenables the mouseclick, but not always.

Can we revert back to an earlier version of Firefox, or do we need to abandon it completely until this is fixed?

Removing all add-ons (I was using Cooliris, webmonkey, video downloader)l reinstalling Flash with full installer, not slim updater did not seem to work -- I also disabled Move networks Quantum media player plug ins, which i did not even know was on my system. Not sure where that came from! Also turned off Audio hijack application. Then I did a complete restart of the computer (not just a restart of Firefox) and that seems to have done the trick. Not sure which, if any of the above add-ons or apps was the culprit, but the complete restart is highly recommended if you are experiencing similar mouse issues. Will repost if it happens again.

This started happening to me yesterday. All plugins are disabled, didn't help. All plugins uninstalled, didn't help. Downgraded to SP3, didn't help. I've also noticed this happen in Thunderbird, though it seems OK now.

Sadly I've had to start using IE8 :(

It's simple. The scroll button on your mouse must be stuck/depressed. Try releasing it or tapping it and then you will have all clickable links in Firefox.

The centre mouse is the culprit.

Yes - this is very debilitating. WinXp Pro

Workstation at work. Once Firefox "fouls", it is like it has lost focus yet is still the topmost window. The only firefox controls that receive focus and are "clickable" by the mouse are the "File, Edit....Help" menu. Not even the actual minimize, maximize & close windows buttons can be selected by the mouse. Nothing (hyperlinks, buttons, etc) on a web page can receive focus from the mouse.

Ctrl-Tab to another app and back...all is well until "something" fouls it again. might be the next click or 20 clicks down the road.

Strangely also seems to cause Excel '97 where once fouled (and regardless of Ctrl-Tab), excel behaves like the shift key is stuck down. endless selecting cells....nothing can by entered using the keyboard.

My laptop is fine. probably very close set of add-ins. mouse driver?

I see both a Logitech USB driver and a MS PS2 driver installed under the device manager. I am using a Logitech Wheelmouse - with a PS2 connection.

Finally plugged a newer USB Logitech mouse in (incorrectly stated my old mouse was PS/2 but it was USB as well) and rebooted and the problem has not occurred in hours. Pretty sure it's ok now....touch wood!

Replaced M-BD58 Logitech mouse with M-UV55a. I didn't change/install any drivers.

I also have similar problem with firefox. No solutions found as yet. Have been using Firefox for the last 8 years, but for the last few years firefox has been usine too many of resources and slowing down my speed. But this latest losing focus thing is a bit too much.

I guess it would be better to start using faster browsers........:(

But I rather use Firefox, please............but how?

I am using Firefox 10.0 and same problem. I will try another mouse.

It's not the mouse. Because it happened to me and I didn't have a scroll button on two of the four "mouses'. It happened on all, same way. Solution: 'option + command + esc' on mac. Open force quit window. Firefox then recognizes my mouse, without having to quit, simply close the force quit window.