MS Viruscan aggressively scanning inbox causing "not responding" error
I had terrible trouble from April 28, 2023 with TB after a update to MicroSoft Viruscan arrived. MS would now scan email for over up to 10 minutes showing wait-circles before it would let me use TB for EACH TIME that TB was used.
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These are some generic suggestions to avoid problems with anti-virus software.
Create an exception in your anti-virus software for the Thunderbird profile folder, so that the anti-virus real-time scanner will not scan it. https://support.mozilla.org/en-US/kb/profiles-where-thunderbird-stores-user-data#w_how-to-find-your-profile
Don't let your anti-virus software scan incoming and outgoing messages.
Don't let your anti-virus software scan attachments.
Don't let your anti-virus software intercept your secure connection to the server.
Remove any add-ons your anti-virus software may have installed in Thunderbird.
Keep it working. http://kb.mozillazine.org/Keep_it_working_-_Thunderbird
And last but not least, backup your Thunderbird profile on a regular basis. https://support.mozilla.org/kb/profiles-where-thunderbird-stores-user-data#w_backing-up-a-profile